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To aid in this increased speed of the fibroblasts, focal adhesion kinase is significantly elevated in fibrotic tissue, and targeting the activity of focal adhesion kinase has been shown to reduce fibrosis [115,116]

Kwon and Park 2015 reported that intra-articular AOD-9604 injections, especially when combined with hyaluronic acid, improved cartilage scores and reduced lameness in a rabbit collagenase-induced osteoarthritis model