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Epilepsia 64:866874

Since mitochondrial ROS are upstream activators of NLRP3 inflammasome and NF-kB pathways, reducing them at the source has downstream anti-inflammatory effects throughout the cell

doi: 10.1097/00007611-198411000-00007 141 TobiMMoragARavidZChowersIFeldman-WeissVMichaeliYet al

Although malabsorption is a plausible mechanism for the vitamin B12 deficiency associated with metformin treatment, normalization of vitamin B12 levels has been observed even after oral administration [57]