glutathione persister cells Sublethal cytochrome c release generates drug-tolerant cells: Cell Low-GPX4 drives a sustained drug-tolerant

Example Calculation: Weight: 150 lbs Conversion: 150 / 2.2 = approximately 68 kg Low End (20mg): 68 x 20 = 1,360mg per day High End (40mg): 68 x 40 = 2,720mg per day Note: These higher ranges are typically used for specific, short-term goals and often involve standard oral supplements where absorption is expected to be low

& Rossi, J

Trial-Reported Endpoints by Phase Trial Lancet 2021 Phase 2 Duration 26 weeks Population Overweight/obese, no T2D (n=706) Mean Weight Loss 10.8% at 4.5 mg vs 3.0% placebo Trial Lancet 2023 Phase 2 Duration 32 weeks Population T2D + obesity (n=92) Mean Weight Loss 8.1% cagrilintide alone

Functions of EpCAM in physiological processes and diseases