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Generally, however, nAbs are much more effective than nnAbs in vivo, which explains the greater research focus on nAbs

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Animal and cellular studies do not reliably predict human outcomes

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Additionally, six genes encoding components of the lipoic acid pathway - specifically lipoyltransferase 1, lipoic acid synthase (LIAS) and dihydrolipoamide dehydrogenase - or targets associated with lipoylated proteins within the pyruvate dehydrogenase complex [including dihydrolipoyl transacetylase (DLAT), pyruvate dehydrogenase E1 subunit 1 (PDHA1) and PDHB] were also identified (196)