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doi:10.1016/j.jep.2016.07.015 Wang J, Xu J, Zhong JB

All fish were housed in 10 L tanks under controlled conditions of constant aeration, mechanical filtration, 27 2 C water temperature, and a pH of 7.0 0.2

Costunolide also improved central nervous system parameters, such as serotonin and norepinephrine levels in the hippocampus, indicating its bidirectional effects on the gut-brain axis