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Under the action of intestinal flora, proanthocyanidins are mainly metabolized to phenylpentanolide and phenolic acid, which can be reabsorbed in the blood, and most of them as well as the metabolites are excreted in the feces 81

The increased ROS level impacts the integrity of the RBC membrane, which impacts the red blood cell (RBC) function, leading to impaired hemostasis and thrombosis