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119 In contrast, tumor-specific neoantigens arise from somatic mutations, gene fusions, or aberrant splicing events 120,121 and are absent from normal tissues, making them highly immunogenic

One of the proposed mechanisms explaining the downregulation of autophagy related to GOF is through autophagosome protein markers, like Atg12 and Beclin1, among others

The exact causes of eczema are not entirely known, but they may stem from a combination of genetic, environmental and immune system factors