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TRIUMPH-CVOT: cardiovascular outcomes trial, approximately 10,000 participants with established CVD, primary endpoint major adverse cardiovascular events (MACE), timeline 3 to 4 years

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(2013) demonstrated by SSNMR that full-length Sup35 and Sup35 (1253) fibrils have different conformation, stressing the fact that amyloid domains might adopt different structures in isolation or in the context of full-length protein assembly