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Consequently, STING activation promotes the lysosomal turnover of GPX4 in neurons experiencing concurrent inflammatory stimulation and excitotoxic insult (163)

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Independently of the type of diabetes involved, the available evidence suggests that the increase in serum oxidative stress is associated with the presence of microangiopathic, macroangiopathic and neuropathic complications of diabetes mellitus.12 Furthermore, the increased production of ROS in diabetic individuals worsens insulin action at the peripheral level and contributes to pancreatic beta cell dysfunction.15 Very few studies have investigated whether the antioxidant capacity in the saliva of diabetic patients differs from that of healthy subjects