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Previous research has indeed indicated that NPs have the potential to enter the CNS and elicit a range of adverse effects

J Biotechnol

However, eye drops containing preservatives like benzalkonium ammonium chloride (BAK) may cause corneal epithelial disruption, which would delay the healing of wounds [276]

This hypothetical adverse effect, although not clinically reported until now, is analogous to the hypothalamic-pituitary axis suppression seen with long-term use of systemic corticosteroids Exacerbation of Helicobacter pylori associated peptic ulcers: Helicobacter pylori is known to feed on macrophages and neutrophils abundant at the site of inflammation caused by the ulcer