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Primarily, VNS increases the release of norepinephrine (NA), which inhibits NF-B activation, subsequently downregulating major histocompatibility complex class II (MHC-II) expression in astrocytes and suppressing the production of proinflammatory enzymes, including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) (9193)

Accordingly, preferably excluded from the present invention are one or more polynucleotides consisting of a nucleotide sequence described by the general formula of a-b, where a is any integer between 1 to 2640 of SEQ ID NO:1, b is an integer between 15 to 2654, where both a and b correspond to the positions of nucleotide residues shown in SEQ ID NO:1, and where b is greater than or equal to a+14

Iannitelli AF, Segal A, Pare J-F, Mulvey B, Liles LC, Sloan SA, et al

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