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In humans, the prevalence of developing cancer-associated cachexia ranges from 31 to 87% (5759), and in 20% of cases it is the main cause of death (59)

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J Cell Physiol 125:151155 Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H, Oshima M, Ikeda T, Asaba R, Yagi H et al (2011) CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth