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DOI: 10.1089/jmf.2017.4080

4.3.3 Cellular lipotoxicity and fatty acids One of the main initiators of macrophage foam cell development and atherosclerosis is the disturbance of regular lipid metabolism in macrophages

administered inhibitors of the renalaldosterone axis to patients with advanced DKD, complemented by KD intervention

The superoxide radical (O 2 ) is considered as the primary ROS and it can further interact with other molecules either directly or prevalently through enzyme- or metal-catalysed processes to generate secondary ROS [5,8]