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Consistency over several months is usually required to see a meaningful difference

10.1016/j.fct.2018.12.008 21 BiX.HeX.XuM.ZhaoM.YuX.LuX.et al (2015)

Endocrinology 130:26972702 Mulroney SE, Haramati A, Werner H, Bondy C, Roberts CT Jr, LeRoith D (1992) Altered expression of insulin-like growth factor-I (IGF-I) and IGF receptor genes after unilateral nephrectomy in immature rats