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doi: 10.1002/adma.202313029 163 BaoYGeYWuMMaoZYeJTongW

The relentless, rolling waves of nausea that hit during dose escalation drive roughly 10-17% of users to abandon treatment entirely, according to data from the STEP clinical trials

In scientific literature, NNMT is recognized as an enzyme that methylates nicotinamide (a precursor of NAD+) using S-adenosylmethionine (SAM) as the methyl donor, converting it to 1-methylnicotinamide (MNA) and potentially affecting cellular NAD+ availability