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2007 Nov;92(11):4379

Metformin may be considered for patients with metabolic complications due to its potential to inhibit hypoxia-induced fibrosis in adipose tissue.40 Oral analgesics may be used for pain management, although systematic data on pharmacological therapies are lacking.8 Despite its association with sex hormones, there is no scientific basis for the use of estrogens, progestins, testosterone, or hormonal implants in the treatment of lipedema