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Inflammopharmacology, 7(1), 114

Springer International Publishing, pp 123

OS in the TME is one of the main factors that mediate the conversion of cell types, such as normal fibroblasts and mesenchymal stem cells to CAFs, which play a key role in tumor cell proliferation, survival, angiogenesis, invasion, inflammation, and ECM remodeling via cross-talk with cancer cells through paracrine signals (Costa et al., 2020)