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(C) Time-dependent inhibition of TGR activity with GSSG

861 Menopause is a risk factor for OA, and epidemiological studies have found that postmenopausal women have a rapidly increased risk of osteoarthritis compared to premenopausal women of the same age, indicating that estrogen level is a key factor in OA development

(2018) identified a distinct microbial signature with elevated Lactobacillus and decreased Veillonellaceae , correlating with greater symptom severity and poorer 12-month remission

In general, replications of the PD-microbiome instances are often poorly developed, presumably as a result of confounding by usage of medication, geographical differences, sequencing methods, and analytical pipelines