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Introduction of Protein Therapeutics and MSNs In 1922 the pancreatic insulin was successfully purified and applied for Leonard Thompson, a 14 years old boy suffering type 1 diabetes, which ushered in the era of protein therapeutics (Banting et al., 1991)

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Insulinregulated aminopeptidase inhibitormediated increases in dendritic spine density are facilitated by glucose uptake

The underlying mechanisms would involve the role of folate and cobalamin in S-adenosylmethionine production which could then support methylation reactions that would stimulate PGC-1 activity in this model