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Chronic alcohol consumption results in ROS formation, bacterial proliferation in the intestinal lumen, alteration of its permeability to macromolecules, bacterial translocation, and Toll-like receptor-dependent activation of Kupffer cells, which drives immune response and cytokine production, resulting in liver necrosis and fibrosis (64, 65)

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+ Hydroxocobalamin-B12 Is a vitamin which is important for the normal functioning of the brain and nervous system, and for the formation of blood