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The findings of the present study are consistent with those of many previous reports, which have provided evidence that SA has anti-secretagogue, anti-ulcer, and gastroprotective activity in ethanol-induced GUs in rats ( 2 ) are produced by neutrophils that react with lipids to produce lipid peroxidation ( 2 ) and ROS, and depletion of antioxidant enzymes caused by scavenging by the superoxide radical anion (O 2 ) and ROS ( The Nrf2/HO-1 signaling pathway plays a crucial role in protecting cells from oxidative-stress-induced injuries by restoring endogenous antioxidant enzymes (GSH, CAT, and HO-1) ( Our histopathological findings further confirmed that ulcerated tissues display erosion of gastric wall mucous barriers with hemorrhagic lesions, extensive edema, and leukocyte infiltration of the submucosal layer

This invention, attributed to Amalia Porta, focuses on synthetic and plant-derived flavonoid compounds represented by formulas (I) and (II)

10.14336/AD.2022.0622 53