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Through bioinformatics analysis and experimental validation, six key genes related to ER stress (epidermal growth factor receptor (EGFR), mesenchymal-epithelial transition factor (MET), insulin receptor (INSR), reticulophagy regulator 1 (RETREG1), MCL1, and basigin (BSG)) were identified, which are closely associated with pathways such as immune response and oxidative phosphorylation [86]

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Some of these limitations have been addressed by developing CAR-T cells that are specific to EBV antigens such as LMP1, since they would be specifically expressed in EBV infected malignant cells (314)