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On the other hand, even minor disturbances in zinc status and zinc homeostasis affect systemic and cellular redox homeostasis

The content of Fe 2+ is strictly regulated, and when its level is out of balance, excess ferrous will provide electron-promoting lipid peroxidation via Fenton reaction, resulting in an increased production of ROS and inducing ferroptosis (Kajarabille and Latunde-Dada 2019

Significant progress has been made in applying gene editing therapies to autoimmune diseases, primarily by modifying immune cell functions to inhibit pathological immune responses