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The other H-site residues (L226, F225 and P33) form van der Waals interactions with the phenyl group of C1-27

High concentrations of 4HNE have been associated with different processes such as apoptosis, cell differentiation, altered gene expression and with several diseases correlated to redox imbalance such as neurodegenerative and cardiovascular diseases, metabolic syndrome, and cancer 15

Autophagy, which facilitates substrate breakdown, is created when autophagosomes attach to lysosomes

35,36 In 1937, Krebs and Henseleit discovered the tricarboxylic acid (TCA) cycle, which converts pyruvate into carbon dioxide and water under aerobic conditions while generating energy