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Improvement in liver histology, including improvement in fibrosis, has been observed in patients receiving interferon or peginterferon in combination with ribavirin, particularly in those with a sustained virological response to therapy59

Ethics declarations Ethics approval and consent to participate This study was performed with the approval of the Ethics Committee of Harbin Institute of Technology University and carried out in compliance with the Declaration of Helsinki of the World Medical Association

Trimethylamine-N-oxide-stimulated hepatocyte-derived exosomes promote inflammation and endothelial dysfunction through nuclear factor-kappa B signaling

The novel ECHO (Early Complications in HCC immunoOncology) score was derived, and the formula for log odds of early death was: -2.100 + 0.574*(ECOG score) + 1.000*(ALBI score) + 0.124*(CP points) + 0.748*(presence of metastases or macrovascular invasion)