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111 Understanding how genetic and epigenetic, neurologic, hormonal, and immune mechanisms contribute to the experience of pain may help patients reconceptualize their condition, feel less anxious, and feel more empowered to make changes that can improve their outcomes

MOTS-c, a mitochondrial-derived peptide, has been studied for its role in AMPK-dependent metabolic regulation (Lee et al., 2015, Cell Metabolism)

However, there was no overall improvement in depression symptoms, pain scores or in the results of a 12-item short form health survey

We are presenting it as the clinical pattern we have seen, with the appropriate caveats that clinical observation is subject to selection bias and confounding