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A phase II RCT showed that the ALT level and hepatic lipid accumulation of NAFLD patients were both decreased after 12 weeks of treatment with EDP-305, but the incidence of side effects, including pruritus and nausea, was also higher [207]

Extensive research on engineered nanomaterials has led to the design of numerous nano-based formulations, i.e., nanomedicines, for theranostic applications with one of the significant benefits lying in the ability to formulate a drug without using dose-limiting toxic excipients present in many current marketed formulations, often enhancing tolerability and containing more active molecules to be administered to patients [655,656]

These changes were accompanied by strong metabolic differences in the faeces, caecal content, liver and gut tissues between TCDF-treated and control AhR +/+ mice, whereas TCDF had no effect on the metabolic profiles of AhR / mice

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