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For scalp, it could theoretically mean temporary worsening of hair appearance

The preserved muscle mass during treatment may provide slight metabolic advantage compared to rapid weight loss through extreme dieting

Furthermore, there is evidence that non-spherical NPs are internalized by cells at faster rates and in larger amounts than spherical NPs (Hadji and Bouchemal, 2022)

Notably, although gallbladder disorders frequently manifest, advanced gastrointestinal complications such as intestinal obstruction and periprocedural aspiration, and emergent concerns regarding suicidality and ocular problems require further longitudinal studies to refine the usage guidelines for GLP-1 RAs in susceptible populations