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While pharmacological treatments remain the standard of care, there is growing interest in adjunctive non-pharmacological strategies, including dietary and lifestyle modifications

Studies have also indicated that gut dysbiosis can lead to behavioral changes associated with depression, suggesting that microbial imbalances may directly affect brain function and emotional regulation [228,229,230]

The benefits and limits of anabolic therapies based on testosterone replacement or use of new selective androgen receptor modulators (SARMs) will be lastly discussed