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Allergy 77:16231625 Samin A, Al Kury LT, Imran-Khan M, Hussain S, Alattar A, Alshaman R, Shah FA, Aamir M, Li S (2021) Acetyl-l-carnitine protects against LPS induced depression via PPAR- induced inhibition of NF-B/NLRP3 pathway

A42 deposition also decreases the level of antiapoptotic protein B cell lymphoma 2 (Bcl-2), upregulates the pro-apoptotic protein Bax, and increases activities of apoptosis-related proteins caspase-3, caspase-9 and cytochrome c (Cytc) in SH-SY5Y cells, ultimately causing apoptosis and neurite degeneration [70, 79, 81]

Mechanistically, fructooligosaccharides can enrich Bifidobacterium in obese mice, activate the cAMP/PKA pathway in intestinal L cells, stimulate GLP-2 secretion, enhance tight-junction protein assembly in the colonic epithelium, improve barrier function, and reduce systemic inflammation (191)

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