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Thymosin alpha-1: the most clinically studied Thymosin alpha-1 (TA1) is a 28-amino-acid peptide that modulates the immune system, supporting T-cell function and helping regulate inflammatory responses

EA at GV20, GV14, BL23 and ST36 can reduce the relative abundance of harmful bacteria (such as the Catabacter , Robinsoniella and Desulfovibrio ), while the relative abundance of Clostridiales-unclassified is upregulated in the EA + probiotics group, they both can improve cognitive impairment in vascular dementia mice ( Acupuncture treatment can also modulate the metabolic pathways

In particular, it was found that NNMT is required for low SAM levels and H3K27me3 repressive state

discovered that bvPLA2 may successfully suppress the development of Alzheimers disease in transgenic mice (Ye et al., 2016b)