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The theory suggests that at the beginning of exercise, lactate is rapidly produced and accumulates in muscle cells

Chem Commun 54:11531169

in vivo , gastrointestinal and liver enzymes are the main agents responsible for isomerization (Ross et al., 2011)

Further support for these findings comes from transcriptome and gene array analyses of liver tissue from dogs with hepatitis and age-related hepatic changes, which suggest the enhanced expression of genes related to OS and inflammation in hepatic dysfunction [95,99]