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J Pharmacol Exp Ther, 82: 377-389

Netherlands Scientific studies have found that the FOXO4-DRI peptide works by selectively inducing apoptosis in senescent cells through disruption of the interaction between FOXO4 and p53 (1)

With respect to age-related diseases, such as AD, and advancing age, it was indicated that the melatonin concentrations in individuals reduce, which is highly correlated with disease progression and genotype (Reiter 1992