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While a biphasic kill curve was observed for the metZ treated with BDQ at pH 7.2, the kill curve at pH 5.5 was predominantly linear, suggesting a lower frequency of persisters formation at acidic pH

This work was supported in part by grants from NIH AG067664, CA252707 and GM157928 to T.G.K., GM146979 to L.W., HL158081 and CA172408 to F.C.Y., and CA279317 to M.A.B., from National Natural Science Foundation of China 82372736 to L.Z., from the Robert H

These therapeutic approaches could also be extended to other neurodegenerative conditions affecting the CNS

Definition and origin DTPs are defined by three fundamental factors: interaction, stochasticity and evolvability (Fig