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Of these four, ORF7a protein is the most potent NF-B inducer and pro-inflammatory cytokine producer.4 N-acetylcysteine is an antioxidant against reactive oxygen species and is a potent NF-B inhibitor.5 Oral N-acetylcysteine administered at 600 mg thrice daily has been shown to reduce mortality in hospitalised SARS-CoV-2 patients.6 The clinical course of our patient suggests that high-dose N-acetylcysteine antioxidant therapy was able to control the cytokine storm of SARS-CoV-2 infection

Respir Med 119:2328

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Fresh frozen plasma (FFP) was administered simultaneously in a 100 mL bolus plus a 150 mL infusion over 90 minutes