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Collagen fibers are susceptible to damage from oxidative stress

(3) The combined structural data and all-atom molecular dynamics simulations indicate that Arabidopsis SNX1 has a reduced membrane affinity compared to mouse SNX1, primarily due to differences in its AH domain, which in turn restricting the formation of longer tubular structures relative to those formed by mouse SNX1

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Moreover, the abundance of free radicals leads to increased oxidative stress, an accelerator and hallmark of aging tied to a myriad of age-related diseases