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First-line treatments usually consist of hormonal treatmentsuch as a hormonal IUD (coil) or continuous use of a birth control pillcombined with a non-steroidal anti-inflammatory drug (NSAID) like naproxen

The heatmap (Supplementary Figure S1) showed distinct clustering between the two treatment groups, further confirming that the observed metabolic alterations were specific to A45 exposure

The final breakthrough of levodopa substitution was achieved after the neurologist George Cotzias described the transforming clinical effects of oral levodopa [12]