intracellular glutathione metabolism and Its Implications for Health Cellular Compartmentalization, Glutathione Transport and

38 Finally, the relatively minor role of FR in physiological folate uptake (compared with RFC) in nonmalignant adult tissues, compared with its enhanced folate uptake in cancer, may offer increased potential therapeutic index as a drug target

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[DOI] [PubMed] [Google Scholar] 41.Damodaran T., Chear N.J.Y., Murugaiyah V., Mordi M.N., Ramanathan S

The acidic microenvironment impairs the production of chondrocyte matrix and may increase cartilage deterioration in OA (50), indicating that PK might play a key function in OA progression and could be an essential target to reverse OA pathogenesis