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IGFBP displacers At least two different IGF-1 analogs have been made, which have an affinity for IGFBPs but have no effect on IGF receptors, thus displacing IGF-1 from IGFBPs and elevating free IGF-1 levels

(2015) European Neuropsychopharmacology , 25(12): 22162225 Examined neural and cognitive processing following ARA-290 administration in human volunteers, providing early evidence of ARA-290s CNS modulatory properties and cognitive relevance

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Conservative dosing, interval monitoring, clear stopping criteria, and documentation rigorous enough that the data contributes to the evidence base rather than just adding another anecdote