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The approaches that are aimed to impede bacterial establishment on various surfaces or to avoid maturation of biofilms, typically exploit some stimuli to control the genes involved in the formation of biofilm [19] such as repressing the expressions of bacterial adhesins [20], inhibition of the biofilm EPS synthesis [21], and provoking Quorum sensing (QS) signals [22,23,24,25], or even eliminate bacteria in biofilms [26]

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The nerves in the pelvic area must continuously send messages to the brain to maintain an erection, and men with erectile dysfunction may have unresponsive nerves in that area