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The transcriptome analysis indicated the depletion of glial markers, enriched in neuronal markers and mRNAs related to the cytoskeleton, translation, and oxidative phosphorylation [189]

Because pyruvate and oxaloacetate are intermediates in gluconeogenesis, gluconeogenesis is impaired and hypoglycemia can result

34 In a similarly sized double-blind, placebo-controlled study of intravenous ketamine (0.2 mg/kg) for treatment of migraine in the emergency department setting, however, ketamine was not superior to placebo for acute pain relief and caused adverse effects of generalized discomfort at 30 minutes and fatigue at 60 minutes, although no serious adverse events occurred

Tirzepatide (Mounjaro, Zepbound) is a once-weekly injectable medication that combines GIP and GLP-1 receptor agonist activity for type 2 diabetes and chronic weight management