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The exact mechanisms of PACS may be multiply overlapping, several hypotheses have been proposed, including persistent viral existence in tissues, dysfunction of vascular endothelium and nervous system, reactivation of latent pathogens and gut microbiota alteration, long-lasting inflammation, and immune dysregulation (Davis et al., 2023)

Specifically, tigecycline (40 g/mL), clindamycin (200 g/mL), and azithromycin (20 g/mL) completely inhibited both basal mitochondrial respiration and maximal respiratory capacity in neuronal cells

Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection

doi: 10.1021/acsami.3c02128 233 FengYWuCChenHZhengTYeHWangJet al