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Conversely, IRP2 is degraded by a [2Fe-2S] cluster-binding E3 ubiquitin ligase 137 , so that its protein levels are significantly elevated during iron scarcity

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However, the levels of cysteine and glutathione were increased in individuals whose systems were stressed by paracetamol overdose, suggesting that NAC increased the amount of cysteine and glutathione when the body requires increased levels of the substrates 7