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SAM-e is not considered an essential nutrient due to the fact that the body is able to manufacture it

doi: 10.1016/j.apsb.2019.12.006 47 MackenzieBEricksonJD

In men, the use of HCG has been studied for its ability to restore natural testosterone production, particularly in cases of testosterone replacement therapy (TRT) or anabolic steroid use, where it helps prevent testicular atrophy