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This suggests that SIRT1 agonists (e.g., resveratrol) could represent a novel therapeutic strategy for cancer by modulating the tumor microenvironment to suppress metastasis and angiogenesis

In addition, while the antibody can be from essentially any mammalian species, to reduce immunogenicity, it is desirable to use an antibody that is of the species in which the antibody and/or immunoconjugate is to be used