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Opportunities Understanding the cellular consequences of GPX4 disfunction will illuminate novel therapeutic targets and druggable pathways Understanding the function of mitochondria in the disease, or any structure or functional changes will open the door for mitochondria-specific therapeutics already available in the market A measurable effect of mitochondrial dysfunction in blood or urine samples could open the possibility to identify clinically significant biomarkers of disease How do variations impact neurological structure and function

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These effects were generally mild to moderate in intensity and were most frequent during the dose escalation period, becoming less common as participants remained on their maintenance dose