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It was found that cells harboring IDH1-R132 and IDH2-R172 mutations in patients with acute myeloid leukemia gained the ability to convert -KG to D-2HG [22]

Retrograde signaling is activated in altered mitochondria, which communicate with the nucleus to reprogram nuclear gene expression

The chemical reactions that regulate the levels of CO 2 and carbonic acid occur in the lungs when blood travels through the lungs pulmonary capillaries