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FBS fetal bovine serum Nle 1 - AnglV 100 ig/ inL 20 of Nle 1 - AnglV 100 ig/ inL D-Nle-Tyr-He-NH-(CI3 4)s-CONH 2 samples were centrifuged at 4C for 5 min at 2300x g to pellet erythrocytes, and the plasma was transferred to clean tubes

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Such direct inhibitory action appears surprising for a peptide thought to be primarily involved in sleep promotion

Preclinical studies indicate sufficient absorption occurs to exert beneficial effects on ulcers, inflammation, and intestinal integrity, while some peptides may be degraded by stomach acid and digestive enzymes