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Prolonged ER stress and activation of the unfolded protein response (UPR) contribute to macrophage apoptosis as substantiated by studies showing that apoptosis and the UPR effector, CHOP, increase with each stage of atherosclerosis in humans, but the largest increase is observed in the vulnerable plaque (175)

Spermidine protects the cardiovascular system, even when mice are exposed to a high-salt diet

Moreover, as previously stated, kidney growth is under IGF-I control

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