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In addition, retrospective reevaluation of patients with a diagnosis of Reyes syndrome who survived has revealed that many, if not most, had an underlying inborn error of metabolism (IEM)

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Yes, but there are two simple reasons why any cysteine-based prodrug does not help us produce more glutathione: NAC is just a form of cysteine which our body is not lacking since our diet contains plenty of it, and more importantly, since the first enzyme responsible for making glutathione in our cells uses cysteine as one of its building blocks, if it is impaired, any amount of cysteine simply wont aid our cellular glutathione production Glyteine works because it bypasses this enzyme altogether, resulting in increased cellular glutathione levels in any individual